Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry

Table 2 Analysis of viscoelastic parameters in albumin-based colloid solutions enriched with prothrombin complex concentrate (PCC) and fibrinogen (FGN). Different PCC concentrations (0.05, 0.1, 0.25, 0.5, 1, 2, 4 IU/ml) were combined with fixed fibrinogen (FGN) concentrations of 4 g/l. The albumin concentration was maintained stable at 5%. Negative controls on PCC-free solutions did not show any measurable ROTEM response (infinite CT). A minimum of three repeats for each concentration step was performed. The value in bold letters is prolonged (>80s) but still reflects the optimal PCC response for CRF composition

*Increasing PCC concentrations over FGN 4 g/l*
PCC conc.^a	0,05	0,1	0,25	0,5	1	2	4
CT^b,*	613 ± 251	337 ± 46	216 ± 50	168 ± 22	117 ± 20	95 ± 40	115 ± 18
A10^c,**	5.7 ± 1.5	6.3 ± 1.5	6.7 ± 0.6	8.3 ± 1.5	10.7 ± 0.6	14 ± 4.3	11.7 ± 2.1
MCF^c,***	6.3 ± 1.5	7.3 ± 2.1	7 ± 1	9.3 ± 2.3	12 ± 1.7	14.3 ± 4.9	12 ± 2.6

*p < 0,0001, Pearson rho 0,9 for1/CT, **p = 0,0013, Pearson rho 0,65, ***p = 0,0063, Pearson rho 0,57
^aPCC concentrations in IU/ml refer to final factor IX concentrations as reference protein in this product
^bCT in seconds. Mean values ± SD
^cA10 and MCF in mm. Mean values ± SD

ISSN: 1757-7241