Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry

Table 3 Analysis of viscoelastic parameters in albumin-based colloid solutions enriched with fibrinogen (FGN) and prothrombin complex concentrate (PCC). Different FGN concentrations (0.5, 1, 2, 4, 8, 12 g/l) were combined with fixed PCC concentrations of 1 IU/ml. The albumin concentration was maintained stable at 5%. Negative controls on fibrinogen free solutions did not show any measurable ROTEM response (infinite CT). A minimum of three repeats for each concentration step was performed. The values in bold letters reflect the optimal FGN response for CRF composition

*Increasing FGN concentrations over PCC 1 IU/ml*
FGN conc. ^a	0,5	1	2	4	8	12
CT ^b,*	4032 ± 1949	620 ± 620	221 ± 90	117 ± 20	154 ± 27	198 ± 1
A10^c,**	n.a.	2.7 ± 0.6	3.6 ± 0.6	10.7 ± 0.6	25.7 ± 4.2	47 ± 1.4
MCF^c,***	n.a.	3.7 ± 0.6	3.3 ± 0.6	12 ± 1.7	26.3 ± 3.1	49.5 ± 3.5

*p < 0,0001, Pearson rho 0,84 for1/FGN, **p < 0,0001, Pearson rho 0,98, ***p < 0,0001, Pearson rho 0,98
^aFGN concentrations in g/l
^bCT in seconds. Mean values ± SD
^cA10 and MCF in mm. Mean values ± SD

ISSN: 1757-7241